Multicatalytic Approach to One-Pot Stereoselective Synthesis of Secondary Benzylic Alcohols

One-pot procedures bear the potential to rapidly build up molecular complexity without isolation and purification of consecutive intermediates. Here, we report multicatalytic protocols that convert alkenes, unsaturated aliphatic alcohols, aryl boronic acids into secondary benzylic alcohols with high stereoselectivities (typically >95:5 er) under sequential catalysis integrates alkene cross-metathesis, isomerization, nucleophilic addition. Prochiral allylic can be converted any stereoisomer product stereoselectivity (>98:2 er, >20:1 dr).